It is also known as Jacobinia carnea, and is a part of the Acanthaceae family along with the Aphelandra squarrosa (Zebra plant) and Crossandra. Buege JA, Aust SD. CAS Control treated group showed normal micromorphological sections. 2003;66:1499503. In winter, you might have to spray the leaves with water, especially if the air is dry. Mean lethal dose of the extract was found to be above 5000mg/kg body weight (bw). In phase two, three rats were separated into 3 groups of one rat per group. Be sure to follow relevant directions on product labels and consult your, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Mediterranean, Low-Fat Diets Are Best for Heart Problems, Least Amount of Exercise You Need to Stay Healthy, Nerve 'Pulse' Therapy May Help Ease Sciatica, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox. https://doi.org/10.3390/molecules191221442. Justicia carnea is commonly cultivated and grown as an ornamental potted plant. Aim. Materials and Methods Plant material Justicia carnea leaves used in this study were collected from Ozalla Isuofia in Anambra State and identified by Mr. Ozioko Not sure which Justicia to pick?Compare All Justicia. This research focused on the safety and in vivo antioxidant status of healthy albino rats exposed to J. carnea leaf ethanol extract. The leaves are rich in carbohydrates and proteins, which are for energy production and maintenance of cellular activities. Anal Biochem. Histopathological examinations of sections of the liver collected from the 4 In this study, nutritive potentials and effects of aqueous extract of Justicia carnea leaves on biochemical indices of anaemic male Wistar albino rats were investigated. 1958;25(1):192205. Different drugs are used but many depend mainly on plants and herbal products for its treatment. Duan WL, Liang XM. Phytother Res 2011;25(3):444-450. Generally disease free. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Paes-Leme AA, Motta ES, De Mattos JCP. They are also needed in strong bone formation, and in cellular and neuronal functions. what are the pros and cons of testosterone replacement therapy? Badami S, Aneesh R, Sankar S, Sathishkumar MN, Suresh B, Rajan S. Antifertility activity of Derris brevipes variety coriacea. The presence of blood boosting nutrients such as iron, copper, zinc and vitamin C can help prevent iron-deficiency anaemia and other anemic conditions. The leaves of Justicia carnea contains powerful antioxidant activities and phytochemical components that help reduce oxidative stress, and reduce the risk of development of cancer. (2020). Also, remove old flowers to keep the plant healthy. Becoming a contributing member of Gardenia is easy and can be done in just a few minutes. However, scientifically it is called Justicia carnea. Extraction was carried out by maceration (72h) following the method of Onoagbe et al., [13]. Evid Based Complement Alternat Med. Springer Nature. Despite the therapeutic importance of medicinal plants, toxic substances have been shown to be present in large numbers of plants investigated [3]. The animals were randomly distributed into cages and allowed to acclimatize for 2 weeks in a well ventilated room under natural lighting condition. B-vitamins are good sources of energy. Rats were routinely observed for signs of toxicity. 2005;102(2):197201. We'll respect your privacy and unsubscribe at any time. Although the antidepressant activity of justicia carnea has not been studied, and so may be hard to prove its efficacy scientifically, the leaves of justicia carnea have been used in traditional medicine to treat depression and anxiety disorder. The levels of white blood cell count, lymphocyte, granulocyte and MID could indicate that ethanol extract of J. carnea leaf pose no toxicity or sub acute inflammation to the overall defense mechanism and immunity of the experimental rats. In-vivo studies have revealed that radicals produced from these dietary antioxidants are constantly regenerated back to their active form by GSH in the ascorbate glutathione cycle. Prof. F.O. When there is high cholesterol level in your blood, LDL- and VLDL- cholesterols are being deposited on the arterial wall of blood vessels, thereby blocking free flow of blood and increasing blood pressure. 16. This later condition is termed insulin resistance. The Hematological system and antioxidant status of rats following 14days of sub-acute exposure tolerated the ethanol extract of J. carnea leaf. Onoagbe IO, Attah V, Luther MM, Esekheigbe A. Hypoglycemic and anti-diabetic effects of Morinda lucida and Tetracera alnifora in normal and streptozotocin-induced diabetic rats. Research reports it isnt capable of causing kidney and liver damage either but dont eat it raw. Extinction coefficient () of MDA TBA complex=1.56105M1cm1. 2007;39(1):4484. Regular intake can reduce your risk of liver diseases like liver cirrhosis, hepatitis and liver inflammation. Mapanga RF, Musabayane CT. As for light exposure, keep the plant away from the full sun. 1983;53:27589. Leaf extract in isoproterenol induced myocardial infarction in albino rats. Ethanol extract of J. carnea leaf elevated red blood cell, hemoglobin, packed cell volume and platelet count with significant increase at higher doses of extracts compared to the control. In the kidney, SOD and MDA level were indistinguishable compared to the control except SOD level in rats that received 800mg/kg JCEE that reduced significantly (p<0.05). In the study conducted by Onyeabor and his colleagues, it was shown that the leaf extract not only reverses anemic condition, but also lowered the lipid profile of the experimental rats. SOD activity was determined by its ability to inhibit the auto-oxidation of epinephrine determined by the increase in absorbance at 480nm. Article Effect of methanol leaf extract of Justicia carnea on serum albumin (ALB) and total protein (TP) concentration CCl 4 intoxicated rats. Karigidi is a lecturer in the Biochemistry unit of Chemical Sciences Department, Olusegun Agagu University of Science and Technology, Okitipupa, Ondo State, Nigeria. In an acute exposure of experimental rats to single oral doses of extract, no mortality and signs of adverse effects were observed. Justicia carnea needs bright, indirect light to thrive. 200, 500 and 1000 mg/kg bw of Justicia carnea showed a significant (p<0.05) decrease in the activities of ALT, AST and ALP, and bilirubin level while total protein and albumin levels increased significantly (p<0.05) when compared with the rats treated with CCl alone. long (25 cm), and showy flower plumes, 8 in. Ogwu obara can act as a blood tonic for women during menstruation. Great for use as a foundation or mass planting, it is also terrific for containers or as a houseplant. Article ID 687197, 2013; p. 13. https://doi.org/10.1155/2013/687197. Keep an eye out for glasshouse red spider mite and glasshouse whitefly. Onyeabo C, Achi NK, Ekeleme-Egedigwe CA, Ebere CU, Okoro CK. In this article i will take you through the nutritional and medicinal benefits of justicia carnea. if you add justicia carnea leaves in avocado seed tea, you may just get yourself the best remedy for cardiovascular diseases. Justicia carnea is a popular ornamental plant, which possesses powerful medicinal values. PubMed What this means is that aside fighting anemia, justicia carnea leaves also improves your cardiovascular health by suppressing the tendency for dyslipidemia. It may also affect the activity of hormones. The aim of this study is to evaluate the safety of ethanol extract of J. carnea leaf assessing the hematology indices, organ antioxidant system and histology in healthy male wistar rats. Over time, they cause atherosclerosis and myocardia infarction. long (20 cm), densely packed with pink to crimson tubular flowers. Emmanuel Sina Akintimehin. J Acute Disease. Also observed is a distortion in the walls of the blood vessels (red arrow), pyknotic hepatocytes and signs of inflammation (red arrow), Photomicrographs of kidney sections stained with Haematoxylin and Eosin (Mag. Section of livers and kidneys were excised and fixed in 10% formalin for histopathology examination. Safety assessment of oral administration of ethanol extract of, $$ \mathrm{Total}\ \mathrm{protein}\kern0.5em =\kern0.5em \frac{\mathrm{Absorbance}\ \mathrm{of}\ \mathrm{sample}}{\mathrm{Absorbance}\ \mathrm{of}\ \mathrm{standard}}\kern0.5em \times \kern0.5em \mathrm{Concentration}\ \mathrm{of}\ \mathrm{standard} $$, $$ \mathrm{Catalase}\ \mathrm{activity}\ \left(\mathrm{U}/\mathrm{ml}\right)=\kern0.5em \frac{\Delta \mathrm{A}/\min \kern0.5em \times \kern0.5em \mathrm{TV}}{\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}} $$, $$ \mathrm{SOD}\ \mathrm{activity}\ \left(\mathrm{U}/\mathrm{ml}/\mathrm{mg}\ \mathrm{protein}\right)\kern0.5em =\kern0.5em \frac{\Delta \mathrm{A}/\min \kern0.5em \times \kern0.5em \mathrm{TV}}{\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}} $$, $$ \mathrm{Concentration}\kern0.5em \mathrm{of}\kern0.5em \mathrm{reduced}\kern0.5em \mathrm{GSH}\kern0.5em =\kern0.5em \frac{\left(\Delta \mathrm{A}\kern0.5em \times \kern0.5em \mathrm{TV}\right)}{\left(\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}\right)} $$, $$ \mathrm{Malondialdehyde}\kern0.5em =\kern0.5em \frac{\left(\mathrm{A}\kern0.5em \times \kern0.5em \mathrm{TV}\right)}{\Big(\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}} $$, https://doi.org/10.1186/s40816-020-00234-4, https://doi.org/10.1016/j.jep.2015.06.005, https://doi.org/10.1016/j.joad.2015.08.006, https://doi.org/10.1016/j.jep.2005.06.013, https://doi.org/10.3109/08860220903367585, https://doi.org/10.1590/S0102-695X2011005000196, https://academicjournals.org/journal/AJPS/article-full-text-pdf/6AA410310867, https://doi.org/10.35841/biomedicalresearch.30-18-666, https://doi.org/10.1016/j.jep.2007.02.011, https://doi.org/10.1186/s40816-019-0104-4, https://doi.org/10.1016/j.fitote.2008.02.005, https://doi.org/10.1016/j.jada.2008.06.430, https://doi.org/10.1016/j.biocel.2006.07.001, https://doi.org/10.1186/s12906-015-0760-y, http://creativecommons.org/licenses/by/4.0/. When it comes to blood boosting and treatment of anemia, justicia carnea has proven beyond doubt to be an effective remedy. All analyzed dataset to support the conclusions of this article is included as tables in the uploaded supplementary files. The Portal triad (blue arrow) composed of the hepatic vein and artery as well as the bile duct (PT), the well distributed hepatocytes (H) (yellow arrow) and hepatic sinusoids (black arrow) are demonstrated across study groups. Make sure to follow the package instructions carefully. Sci. Absorbance reading was taken at 620nm regularly at an interval of 1min against reagent blank. Exactly 1.0ml of tissues (liver and kidney) was deproteinised using 0.1ml of 10% TCA and centrifuged at 650g for 5min to obtain supernatant. The leaves of justicia carnea possess high content of iron and vitamin C. This compounds may be responsible for the blood boosting property of ewe eje leaves. Powdered sample was extracted using absolute ethanol and concentrated to obtain a slurry paste of J. carnea ethanol extracts. statement and . From this study, the significant increase in platelet counts suggested that the extract could be useful in preventing excessive blood loss (through blood clotting) and resistance of capillary membranes to leakage of red cells when blood vessels are damaged. Why urban citizens in developing countries use traditional medicines: the case of suriname. Previously, J. carnea leaf has been reported to contain high quantity of phytochemical constituents (such as saponins, alkaloids and terpenoids), vitamins (A, C and E) and minerals [9, 10]. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The description of these plants has been written based on numerous outside resources. View abstract. 2015;174:61827 https://doi.org/10.1016/j.jep.2015.06.005. In sub-acute toxicity study, total of thirty (30) rats were randomized into six groups of five rats per group: Group 1 served as control and was administered with 1ml of distilled water (dH2O). It also grows in some Caribbean islands, including Trinidad and Tobago . The kidney of rats treated with doses of J. carnea ethanol extract revealed dose dependent degree of renal injury (Fig. Oral acute toxicity study on J. carnea ethanol extract (JCEE) was carried out according to Lorke [15] method using the total of twelve (12) albino rats in two phases. International Journal of Biochemistry Research & Review. Occupational Health and Safety in the Care and Use of Research Animals. Related: The Persian Shield plant is also in the Acanthaceae family. de Vries, J. X., Tauscher, B., and Wurzel, G. Constituents of Justicia pectoralis Jacq. Justicia carnea and Cnidoscolus aconitifolius were tested for their capacity to ameliorate the fecundity of chloramphenicol-induced lymphoma in rats. They range in colors such as red, orange, mauve, magenta, apricot, and pink. Create a beautiful garden with this colorful and Use our interactive toolsto design your dream garden. The result from the kidney histology could be due to the presence of active secondary metabolites and daily dosing of the extract. Rats in the 3 different groups received 10, 100 and 1000mg/kg body weight of JCEE orally using oral gavage. Total protein concentration in tissue homogenates were determined using biuret method Tietz [16]. Rats that received 50 and 100mg/kg body weight JCEE showed significant (p<0.05) increase in liver weight while other doses showed no significant difference compared to the control. This post was last modified on January 2, 2023 5:23 pm. 2013;3(4):1248 https://doi.org/10.7324/JAPS.2013.3422. W Afr J Biol Sci. 1978;90:819. The plant produces dark green leaves around 8 inches in length. The renal cortex showed normal glomeruli with mesangial cells and capsular spaces appeared normal (white arrow), the renal tubules appear normal (blue arrow) and interstitial spaces also observed normal (black arrow). J Ethnopharmacol. PubMed Central Ewe eje improves the production of white blood cells and other antibodies, all which are essential for strengthening immunity. This lends the plant some interesting names such as Blood of Jesus plant and Hospital too far. Chariandy, C. M., Seaforth, C. E., Phelps, R. H., Pollard, G. V., and Khambay, B. P. Screening of medicinal plants from Trinidad and Tobago for antimicrobial and insecticidal properties. J Nat Prod 1988;51(4):804-805. 2015;15:236. https://doi.org/10.1186/s12906-015-0760-y. (2017). Infertility after therapy, in particular, imposes a significant mental strain on young patients. Provided by the Springer Nature SharedIt content-sharing initiative. Stover PJ, Caudill MA. Justicia pectoralis might have many different effects in the body. Justicia carnea is a medicinal plant that is used conventionally as blood tonic from time immemorial in Nigeria. Oso BJ, Oyewo EB and Oladiji AT. Aim. Corra, GM., de C. Alcntara, AF. When you boil the plant, it turns the water red. Chidubem Olovo is a biochemist and a researcher whose interest is centered on the chemistry of natural products, their pharmacological properties and how using the plant sources can improve human healthy living. There may be some problems if the air is too dry in winter. Vitamin B aids in the formation of red blood cells and helps to build tissues. Studies have shown that ewe eje isnt capable of causing damage to the liver. Pot the specimen and bring it indoors to add a bright touch of color to your interiors. The findings show that ethanol extracts of Costus afer and Justicia carnea could operate as main antioxidants and free radical scavengers. Pinch out tips to promote compact plants. The significant decrease in kidney GSH at 1200mg/kg could be due to ample dietary bioactive constituents in the extract that requires frequent conjugation of GSH in the cell or oxidation to oxidized glutathione (GSSG). The perennial plant puts on a never-ending show of radiant flowers from early spring to fall. 1999;9:18. At the end of 14th day of administration, rats were allowed to fast overnight, sacrificed to collect samples for biochemical analysis and histopathological examination. Materials and Methods View abstract. At the end of the 14th day of administration, the rats were allowed to fast overnight and sacrificed the following morning by anesthetizing each rat in a closed chamber containing drops of chloroform. The Pros and Cons of Creatine You Should Know. Water your plants deeply during growth periods, allowing the soil to dry . Ethnomedical study and iron content of some medicinal herbs used in traditional medicine in cote divoire for the treatment of anaemia. Sun M, Zigma S. An improved spectrophotometer assay of superoxide dismutase based on epinephrine autoxidation. 217-230. It is cultivated and sold as a decorative potted plant and is planted in landscaping as a feature plant in warm . Parameter that were determined include total haemoglobin concentration (HGB), packed cell volume (PCV), red blood cell count (RBC), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), mean corpuscular volume (MCV), white blood cell count (WBC), Lymphocyte count (LYM), MID sized cell (MID), Granulocyte Count (GRM) and platelet count (PLT). Too much fertilizer is damaging for your plant. Onyeabo, Chimaraoke & Achi, Ngozi & Chima, Ekeleme-Egedigwe & Ebere, Chidinma & Okoro, Chidinma. 2010;32(1):1328 https://doi.org/10.3109/08860220903367585. The resultant liquid after boiling is usually crimson red. Omogunwa is a graduate of Biochemistry from the Department of Chemical Sciences, Olusegun Agagu University of Science and Technology, Okitipupa, Ondo State, Nigeria. Fresh leaves of Justicia carnea were collected from Okitipupa area Ondo State. Studies have shown that ewe eje contains antioxidant and cardio-protective properties. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. 2012;9(1):817 https://doi.org/10.4314/ajtcam.v9i1.12. Recently, it has also been reported that the species possess cardioprotective properties, antioxidant and are generally rich in vitamins and minerals [10,11,12]. Studies have also confirmed this claim. Olumese FE, Onoagbe IO, Eze GI, Omoruyi FO. How long does it take for Aju mbaise to work. https://doi.org/10.1016/j.jep.2007.02.011. Mr. E.S. Once the roots have established, adjust watering to three to five days apart. J Ethnopharmacol. Ewe eje as a Natural Blood booster/tonic: Due to the high concentration of iron in this leaf, it can help boost blood production by increasing the red blood cells, haemoglobin, and the blood platelets. 2012; 22(1):220238; https://doi.org/10.1590/S0102-695X2011005000196. So lets go through this together. OTHER NAME(S): Achille Millefeuille, Achille Mille-Feuille, Ana. In a reaction mixture containing 0.01M phosphate buffer (pH7.0), 0.5ml of 0.2M H2O2 and 0.4ml distilled water, 0.5ml of sample was added. 3. With exception of low doses that showed normal morphology of the hepatocyte and sinusoid that is not infiltrated, high doses of extract greater than 500mg/kg showed mild fat congestion in the central venules with liver parenchyma showing area of hemorrhage compared to the control.