Dashed line indicates the point estimate of the overall effect; dotted line, no effect; diamonds, overall effects. Ensuring COVID-19 vaccine safety in the US. Multimorbidity and adverse events of special interest associated with Covid-19 vaccines in Hong Kong. C, Sun
LD, Doubrovinskaia
WebShingrix can make the area where you get the shot swell or feel sore. , Kaulen
The symptoms below require emergency care and relate to the main serious side effects. S. T. For data selection, the records obtained from different search databases were first transferred to EndNote software, version X9 (Clarivate Plc). There was, however, no significant increase in BP after administration of the messenger RNA SARS-CoV-2 vaccine in pooling 8 observational studies (13518026 doses vs 13510701 unvaccinated; OR, 0.70; 95% CI, 0.42-1.16; I2=94%). JF, Granath
JH. et al. After internal reviews of the reports, the CDC "did not find any data suggesting a link between Covid-19 vaccines and tinnitus," an agency spokesperson said in an email. Clinical features of varicella-zoster virus infection. You can learn more about how we ensure our content is accurate and current by reading our. Clipboard, Search History, and several other advanced features are temporarily unavailable. K, Mano
Bells palsy after second dose of Pfizer COVID-19 vaccination in a patient with history of recurrent Bells palsy. , Hamid
The Egger and Peter tests both yielded nonsignificant results; hence, no publication bias was detected. JA, Tamborska
GBS causes inflammation of the nerves and can lead to numbness, weakness and pain, usually in the feet, hands and limbs and can spread to the chest and face. Proposal of a quality assessment tool for the evaluation of the methodological quality of self-controlled case series and self-controlled risk interval study designs. AA. Myocarditis is inflammation of the heart muscle, and pericarditis is inflammation of the outer lining of Gagnier JJ, Kienle G, Altman DG, Moher D, Sox H, Riley D. The CARE guidelines: consensusbased clinical case reporting guideline development. This study has pooled data on more than 53 million vaccine doses for meta-analysis. 2023 Jan 20;11(2):236. doi: 10.3390/vaccines11020236. Lopez Bernal, J. et al. EMA has advised people to seek immediate medical attention if they develop weakness and paralysis in the extremities progressing to the chest or face following the Covid vaccine. Kharoubi
Safety of the BNT162b2 mRNA Covid-19 vaccine in a nationwide setting. MC, Liaqat
Reports of serious neurological events following COVID vaccination are rare. Estimators of the Mantel-Haenszel variance consistent in both sparse data and large-strata limiting models. Association between vaccination with the BNT162b2 mRNA COVID-19 vaccine and Bells palsy: a population-based study. Furthermore, studies comparing the BP incidence after SARS-CoV-2 infection with SARS-CoV-2 vaccines included different study intervals and did not mention the prevalent SARS-CoV-2 subtypes at the time each study was conducted. W. , Barda
Funnel Plot for Observational Studies on mRNA Vaccines: Vaccinated vs Unvaccinated, eFigure 6. G, Vandebosch
This site needs JavaScript to work properly. U. This systematic review and meta-analysis of pooled randomized clinical trials found that the incidence of BP was significantly higher in vaccine vs placebo recipients. The vaccine-induced multiple sclerosis (if proven) may also be an autoimmune response to the vaccine distribution and transfection to the nerves. , Poudel
B,
R, Mishra
One of the subjects was later diagnosed with multiple sclerosis [5], declared unrelated to the vaccine. , Falsey
SJ, Kitchin
, Bardage
, Gonzlez-Enrquez
Rare Side Effects of COVID Vaccines Myocarditis and the COVID-19 Vaccines. CSL,
It was also not possible to control for some of the known BP risk factors, such as diabetes, obesity, hypertension, upper respiratory tract disease, or pregnancy, because most studies have not provided sufficient data on these risk factors.102 In addition, the recorded BP cases following vaccination might have been prone to a reporting bias from heightened awareness because researchers have constantly sought to record adverse events during the COVID-19 pandemic. Overall, no publication bias was observed among the studies with the Peter test P value of 0.34 (eFigure 5 in Supplement 1). S, Badr-Eldin
This stems from rare reports of people experiencing neuropathy symptoms after receiving one of the vaccines. Gadolinium-enhanced MRI of the brain revealed enhancement in the left facial, trigeminal and oculomotor nerves, which persisted upon repeated examination. Case reports of acute transverse myelitis associated with mRNA vaccine for COVID-19. Laser treatment for neuropathy: What to know, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, Non-arteritic ischemic optic neuropathy (NAION): What to know. In some cases, the neuropathic symptoms can be serious. Bells palsy as a possible complication of mRNA-1273 (Moderna) vaccine against COVID-19. Accessed March 2, 2023. MT, Lee
Of note, the study by Voysey et al58 was not included in the meta-analysis because these investigators reported 4 RCTs of Oxford/AstraZeneca in 3 distinct geographic regions in which the placebo was not solely specified as saline but was a viral vaccine other than a SARS-CoV-2 vaccine (ie, meningococcal group A, C, W, and Y conjugate vaccine). This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline and was conducted with the random- and fixed-effect models using the Mantel-Haenszel method. , Lim
An official website of the United States government. Bell Palsy in Groups of SARS-CoV-2 Infection vs SARS-CoV-2 Vaccine Recipients, With Data From Observational Studies, Table. World J Clin Cases. Second, potentially eligible records were further evaluated using the full texts. MMWR Morb Mortal Wkly Rep 2021;70:10941099. G, Carrafiello
GJ, Ishii
, Kennedy
et al. F, Iskander
I, Ortqvist
The COVID-19 vaccine has some associations with Bells palsy. Importantly, although this study shows evidence of increased BP incidence following SARS-CoV-2 vaccination compared with placebo receipt, SARS-CoV-2 infection was associated with a 3.23-fold increase in BP incidence. 2023 American Medical Association. Y, Khurana
, Sohrabi
In rare cases, the following conditions have occurred after COVID-19 vaccination: One of the neuropathies with a link to the COVID-19 vaccine is GBS, a rare condition in which the immune system damages nerve cells. [Color figure can be viewed at, Median time (days) from vaccine injection to adverse event onset, inclusive of all COVID vaccine types, and proportion of events which were reported after the first or second dose of a mRNA vaccine (using data available in 235,293/275,575 [85%] of patients who received either Pfizer or Moderna vaccines). S. (D) The contrast enhancement of the trigeminal nerve persists upon repeated examination a month later (blue arrow). et al. Phase 3 safety and efficacy of AZD1222 (ChAdOx1 nCoV-19) COVID-19 vaccine. World Health Organization. Several mechanisms have been considered to explicate the underlying pathophysiology of BP. The outcome of interest was BP occurring as an adverse event in the time frame after the vaccination or the respective time frame in the placebo recipients or unvaccinated matched participants. P, Liu
Neurological and autoimmune disorders after vaccination against pandemic influenza A (H1N1) with a monovalent adjuvanted vaccine: population based cohort study in Stockholm, Sweden. MRF. , Hwang
L. The occurrence of BP did not differ significantly between recipients of the Pfizer/BioNTech vs Oxford/AstraZeneca vaccines. Learn more about the link between the COVID-19 vaccine and Bells palsy. The association between COVID-19 vaccination and Bells palsy. To compare the incidence of BP in SARS-CoV-2 vaccine recipients vs unvaccinated individuals or placebo recipients. These autoimmune responses may well be transient in many healthy subjects, and the immune response is likely to be very selective towards vaccine transfected cells only, however, the possibility of developing a chronic autoimmune condition in some individuals cannot be overruled. Learn more here. N, Dagan
S,
J Neurol Neurosurg Psychiatry 2021;92:11441151. , Castaldo
However, for the viral vector vaccine subgroup, the analysis yielded insignificant results (OR, 1.80; 95% CI, 0.26-12.35; I2=0%; Cochran Q P value=0.89). J,
2023 Mar 27;38(12):e95. It can affect the PNS. G, Schneider
How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, The link between peripheral neuropathy and the COVID vaccine, Disorders of the PNS associated with COVID vaccine, Centers for Disease Control and Prevention (CDC), https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707152/, https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-july-13-2021?utm_medium=email&utm_source=govdelivery, https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety.html, https://journals.lww.com/jfmpc/fulltext/2022/07000/small_fiber_neuropathy_as_a_complication_of.120.aspx, https://www.cdc.gov/vaccinesafety/concerns/guillain-barre-syndrome.html, https://www.ninds.nih.gov/health-information/disorders/peripheral-neuropathy, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780646/, https://www.fda.gov/media/144245/download, https://www.hematology.org/covid-19/vaccine-induced-immune-thrombotic-thrombocytopenia, New clues to slow aging? The regulatory authorities are, therefore, requested to review the cases of GBS in association with various other neuropathies and vaccine biodistribution data from preclinical trials. RR indicates risk ratio; SIDIAP, Spanish database of Information System for Research in Primary Care. Clipboard, Search History, and several other advanced features are temporarily unavailable. In the cohort studies,41-46 the analysis indicated no significant evidence of increased odds of BP in the vaccinated group compared with the unvaccinated group (OR, 0.59; 95% CI, 0.34-1.01; I2=94%; Cochran Q P value<.001). SK. N, Greenland
A, Iwatsubo
Published online April 27, 2023. doi:10.1001/jamaoto.2023.0160. Summary of Studies Included in the Meta-analysis on Bell Palsy and SARS-CoV-2 Vaccination, Tiemstra
One proposed mechanism is nerve compression within the temporal bone due to the perineural inflammation and subsequent edematous nerve bundles in response to viral infections,102 such as herpes zoster, varicella zoster,60 or Epstein-Barr viruses.103 These neurotropic viruses are also reportedly associated with neurologic complications, such as GBS, neuropathies, olfactory dysfunction, aseptic meningitis, and encephalitis.104-106 Similarly, vaccination has been a crucial means to reduce this overwhelming burden of viral infections for these viruses.
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